I've just watched the bit about the ACE receptor. The virus targets this receptor but I'm still not sure why high blood pressure matters...unless the receptor being more active simply means it can be targeted more easily? Not got a medical background so bit out of my depth!!
SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)
- Thread starter Don't Kill Bill
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In the latest episode of the United Hour Podcast, Nik (@Rood) is joined by CEO Duncan Drasdo and Financial Director Andy Green from the Manchester United Supporters Trust for a special episode on all things behind the scenes at Old Trafford including a brief history of MUST and their aims today, views on INEOS and Sir Jim Ratcliffe so far, and the Old Trafford regeneration.
I've just watched the bit about the ACE receptor. The virus targets this receptor but I'm still not sure why high blood pressure matters...unless the receptor being more active simply means it can be targeted more easily? Not got a medical background so bit out of my depth!!
Is the number of ventilators really a rate limiting step here? Surely a lack of staff qualified/trained to use them will be the big issue by the time we hit the peak? We have SHOs being given crash courses in how to be an ITU reg but if our current rate of HCW infection continues I wouldn’t be surprised if we end up with ventilators not being used because we’ve run out of people who know how to use them.
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The theory is that certain drugs cause more ACE receptors to be expressed inside our airways because they work by inhibiting the natural enzyme that binds to them (they’re called ACE inhibitors and are used to treat high blood pressure). Which gives more targets for the virus to bind to. Which causes a greater viral load and a worse outcome. It’s just a theory though. Not proven. There are also theories that these same drugs might actually improve outcomes.
Edit: the hospital housekeeper who goes into every breakroom etc. around my wife's ICU has tested positive.
I guess now it isn't an if, but a when
I'm wrecked right now
This person might have infected the entire fecking unit
I guess now it isn't an if, but a when
I'm wrecked right nowThis person might have infected the entire fecking unit
Thanks, that's interesting. Think I'm going to cut back on the lockdown evening beers to make sure it isn't increasing my blood pressure just to be on the safe side.
Wow 381 deaths in the UK today... =/ I mean, we all know this is coming but it still hits hard....
Was it not always a when?One of the nurses in my wife's ICU has tested positive.
I guess now it isn't an if, but a when
It's crazy how everyone is guessing at the moment. It really is like a disaster movie with the harried scientists.
Well shit man, I'd like to think my wife's PPE would protect her. But thanks. I failed to realize the fecking housekeeping lady was Typhoid Mary.
I noticed a lot more dog walkers too last week, but today there seemed to be fewer, some must have remembered they don't particularly enjoy it. Same on a really sunny day, I see lots of dog people out who you just never see the rest of the time. Shame for the dogs really.
As for the park in general, the police are very visible and seem to have done a good job moving on the groups of lads that were meeting up there and swaggering about the paths leaving no room to pass them easily, but they're ignoring people sitting or standing around on their mobile phones. Exercise seems a very flexible concept.
What do you do with a ventilator when it stops being a ventilator?
There will be a world wide glut of the things when this is all over, maybe Dyson are designing one that converts into a carpet cleaner when its ventilating days are done?
There will be a world wide glut of the things when this is all over, maybe Dyson are designing one that converts into a carpet cleaner when its ventilating days are done?
It all feels like a movie to be fair. I still keep thinking it's really just a bad dream and we are going to wake up from it soon.
This recession will be far worse than 2008 if we are in lockdown for 12-18 months (until vaccine). Much worse. Hell, even 6 months of lockdown, which is IMO the absolute minimum, will hit economy much, much harder.
Probably keep it until this happens again...
Am I the only one who has no problem with the police going overboard with enforcing the lockdown?
The media are now going after the police, saying it's heavy handed to clamp down on people driving to remote locations for exercise. It has even lead to the government to tell the police not to be so heavy handed.
As far as I'm concerned, the cops can't be heavy handed enough. People have behaved like idiots. Telling the police to back down and let people carry on being idiots sends the wrong message.
The media are now going after the police, saying it's heavy handed to clamp down on people driving to remote locations for exercise. It has even lead to the government to tell the police not to be so heavy handed.
As far as I'm concerned, the cops can't be heavy handed enough. People have behaved like idiots. Telling the police to back down and let people carry on being idiots sends the wrong message.
Agree. People think they can still do what they want it's a joke.
4053 new cases in Italy
837 deaths
About the same as yesterday but significantly less than a week ago.
837 deaths
About the same as yesterday but significantly less than a week ago.
Better to have them and not need them than to need them and not have them.
You gave a me a pretext to share what the police does in Burkina when you don't respect the curfew.
In normal times I frequently travel by car to walk in the hills and the Derbyshire police action and publicity certainly brought it home to me that I shouldn't. Well done Derbyshire police.
By 2050, every household will have a ventilator, if these new viruses keep cropping up to threaten humanity.
What? There's a difference of about 150 thousand confirmed cases.
UK catching up to the US overnight it seems.
Just hearing that Chris Cuomo of CNN has Covid-19
https://www.cnn.com/2020/03/31/media/chris-cuomo-coronavirus/index.html
https://www.cnn.com/2020/03/31/media/chris-cuomo-coronavirus/index.html
You gave a me a pretext to share what the police does in Burkina when you don't respect the curfew.
And in Kenya police have shot and killed a 13 year old boy whilst enforcing curfew. It sounds like they fired live rounds and a stray bullet hit the boy sadly.
https://www.bbc.co.uk/news/live/world-africa-47639452
People who say that the cure is worse than the disease must be forgetting that thousands are dying and hospitals are at the breaking point right now, with the measures we've taken. With no measures, it would be worse, and it would be getting much worse (and Sweden might be an example if lighter measures, but there are still fairly strict measures that would have dire consequences for the economy anyway). This isn't a choice between strict measures and recession, because the recession would be happening anyway. Do you think everyone would be going on holiday? Going out to shop?
Damn , best of luck my man. Wishing you and her the best possible scenarioEdit: the hospital housekeeper who goes into every breakroom etc. around my wife's ICU has tested positive.
I guess now it isn't an if, but a when
This person might have infected the entire fecking unit
This is why the government's actions need to be from the bottom up. If we repeat a 2008 style bailout of the richest and largest corporations from the top-down there will be much bigger disasters. We have to move away from "socialism for the rich, wild west, laissez-faire capitalism for the poor"
What will always stun me about this virus is the variety of reaction there is to it, from people not feeling anything or slightly ill to those suffering immensely before dying.
Bongs.
I know researchers are looking for a genetic component to this but I wonder if a lot of the variance could be due to the infectious dose received. There’s been a couple of papers on this and it may perhaps explain why medical practitioners seem more likely to get severe disease.
I honestly don't know what the best solution would be, but that's why the world leaders have so much information at their disposal and so many experts who could analyse the different scenarios and outcomes. They should have been prepared and they must take immediate actions to find a global consensus on what the best measures are for both the current time and for the future. The Western world especially is not prepared to go back to a different lifestyle. I even predict that this crisis will lead back to the usage of raw materials that heavily pollute the ecosystem, because it would be cheaper and more effective, which again will go against the whole new Western policy that was paving the way for cleaner energy production.
What I'm certain of is that in such critical events, the most rich and powerful always use the moment to solidify their positions, whilst the rest suffer sometimes irreversible losses.
You gave a me a pretext to share what the police does in Burkina when you don't respect the curfew.
I guess when the inevitable social unrest in poor areas and regions begins, you guys would advocate for the military to step in.
Apparently young, healthy people have suffered a bit as well. Dybala and Gary Lineker's son both reported feeling out of breath within minutes of doing anything physical.
Agreed. It's why I think a different approach is going to be needed after the next 3-4 weeks.
The scandinavians should be exempted from being an example of how civilized people can be, they're a special breed there.
To put things in some perspective though, 1500 people die in the UK every single day on average.