A thread full of good suggestions!
SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)
- Thread starter Don't Kill Bill
- Start date
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In the latest episode of the United Hour Podcast, Nik (@Rood) is joined by CEO Duncan Drasdo and Financial Director Andy Green from the Manchester United Supporters Trust for a special episode on all things behind the scenes at Old Trafford including a brief history of MUST and their aims today, views on INEOS and Sir Jim Ratcliffe so far, and the Old Trafford regeneration.
Moderna vaccine Phase I results just been published in NEJM. Look pretty good too. Bumped their share price 16%.
I saw that article. I am going to tamp down my enthusiasm, but it does look promising. I think this would be the first mRNA vaccine ever approved, right? The concept of mRNA vaccines is hella cool and eliminates some of the concerns with attenuated virus or protein antigen based vaccines. Keeping my fingers crossed.
I’m interested to know what life is like in most of China, or previously sketchy areas that quickly got the virus under control like parts of Japan and S. Korea. Has life returned to normal for you yet? Are you able to move around freely, go to bars and restaurants and use trains/transport as you did before? Or are there still big measures in place, measures that we should still be following in the UK?
"The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified."
I have no idea who that is but I am going to assume he is an asshlole from that post and his twitter handle.
my old PI worked on targeted RNA therapies and he quoted eye-watering prices for a single dose. i'm not 100% sure why the manufacturing is so difficult - it cn't be just making the sequence itself - but i wonder if that will change for the massive mass production this might require.
I believe that rna vaccines are theoretically cheaper and faster to produce when scaled up. I'd guess the high price is because we have never done this yet.
I don’t even think production will be an issue. I look at the price of custom oligo production when I got to grad school in 2002, it’s not even close to the same.
I think the real issue is going to be transport and stabilization. mRNA is crazy unstable, and shipping doses at -80 or in storage solutions chock full of ribonuclease inhibitors is probably a no go. I am not sure if any of the commercial room temp storage option (like RNAstable) are usable.
Long story short there are reasons why rna vaccines have yet to make their debut even though they off advantages. Nothing like a pandemic induced dumping of cash to speed it along.
the replies.. good lord!
Batshit crazy.
I hope they don’t breed.
I hope they don’t breed.
https://m.timesofindia.com/city/ben...mcris-icus-have-died/articleshow/76970141.cms
89 out of 90 patients who were intubated passed away, at a hospital in Bangalore, India
89 out of 90 patients who were intubated passed away, at a hospital in Bangalore, India
These kind of opinions seem to be increasing against any covid related tweets. Especially the idea that the tests are all just showing colds.
Coronavirus: nurses not wearing masks led to A&E closure, inquiry finds
Exclusive: training session at Hillingdon hospital resulted in 70 staff being quarantined
https://www.theguardian.com/uk-news...wearing-masks-led-to-ae-closure-inquiry-finds
Well, this is a bit stupid. And shows how difficult this will remain to control in many places. 1 person spread it to 16 others...
Exclusive: training session at Hillingdon hospital resulted in 70 staff being quarantined
https://www.theguardian.com/uk-news...wearing-masks-led-to-ae-closure-inquiry-finds
Well, this is a bit stupid. And shows how difficult this will remain to control in many places. 1 person spread it to 16 others...
Kinda looking forward to the emerging theories as to why all these people are dying in Texas, Florida, etc, given the virus doesn't exist.
Sounds good! Is this the same sort of approach the Imperial vaccine is based on as well?
"The US health system is so bad that people easily die of a common cold."
That's not even outlandish.
How is an enclosed office environment different from a shop environment?
Coronavirus: Matt Hancock rejects face coverings for offices
https://www.bbc.co.uk/news/uk-53415030
Coronavirus: Matt Hancock rejects face coverings for offices
https://www.bbc.co.uk/news/uk-53415030
Offices should be putting in place social distancing measures is the main reason i think. There's a big difference between wearing one for a brief shop visit where social distancing isn't possible and all day at your desk when you're already 2 metres apart.
But saying the US health system is substantially worse at dealing with the common cold this year, in a number of red states, doesn't really give the message they're looking for - that Democrats are making this up to affect the election.
Like, it basically has to be that Dems are killing people?
I know. But there is no way out of it, either the virus is real or the US health system is shoddy or both. The Trumprites don't realize that they are not helping their cause with their nonsense.
The absolute egos on these people that the whole world would shut down their economies for months just to target republicans and their president. A group who make up less than 1% of the world's population.
"If it wasn't for Obamacare and the Dems blocking Trumps wonder drugs we'd have saved them all".
It'll be some bollocks like that but with a lot more capitals.
I think the Imperial vaccine is an rna vaccine but I don't know how similar it is to the one reported on here.
They have already had to come up with a change of narrative to explain why it's not only happening in 'Dem states' now. Mental gymnastics worthy of olympic medals.
There is big difference and it’s not one that supports wearing them in shops over wearing them in offices.
I just want to know if hospitals can just say “feck you” and send it to the CDC anyway?The first comment is relieved that transparency will finally be served.
Next Monday there will be zero cases and announcment he has defeated the virus
You come here looking for genuine information about the virus, which you do get and is great, but you leave wondering how America is so broken.
Cue a case chart with sharpie lines pointing downward.
https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
Looks like a vaccine developed in the US works. Phase1 open label trial
New England Journal of Medicine
ORIGINAL ARTICLE
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
List of authors.
DOI: 10.1056/NEJMoa2022483
BACKGROUND
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein.
METHODS
We conducted a phase 1, dose-escalation, open-label trial including 45 healthy adults, 18 to 55 years of age, who received two vaccinations, 28 days apart, with mRNA-1273 in a dose of 25 μg, 100 μg, or 250 μg. There were 15 participants in each dose group.
RESULTS
After the first vaccination, antibody responses were higher with higher dose (day 29 enzyme-linked immunosorbent assay anti–S-2P antibody geometric mean titer [GMT], 40,227 in the 25-μg group, 109,209 in the 100-μg group, and 213,526 in the 250-μg group). After the second vaccination, the titers increased (day 57 GMT, 299,751, 782,719, and 1,192,154, respectively). After the second vaccination, serum-neutralizing activity was detected by two methods in all participants evaluated, with values generally similar to those in the upper half of the distribution of a panel of control convalescent serum specimens. Solicited adverse events that occurred in more than half the participants included fatigue, chills, headache, myalgia, and pain at the injection site. Systemic adverse events were more common after the second vaccination, particularly with the highest dose, and three participants (21%) in the 250-μg dose group reported one or more severe adverse events.
CONCLUSIONS
The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified. These findings support further development of this vaccine. (Funded by the National Institute of Allergy and Infectious Diseases and others; mRNA-1273 ClinicalTrials.gov number, NCT04283461. opens in new tab)
Looks like a vaccine developed in the US works. Phase1 open label trial
New England Journal of Medicine
ORIGINAL ARTICLE
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
List of authors.
- Lisa A. Jackson, M.D., M.P.H.,
- Evan J. Anderson, M.D.,
- Nadine G. Rouphael,
DOI: 10.1056/NEJMoa2022483
BACKGROUND
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein.
METHODS
We conducted a phase 1, dose-escalation, open-label trial including 45 healthy adults, 18 to 55 years of age, who received two vaccinations, 28 days apart, with mRNA-1273 in a dose of 25 μg, 100 μg, or 250 μg. There were 15 participants in each dose group.
RESULTS
After the first vaccination, antibody responses were higher with higher dose (day 29 enzyme-linked immunosorbent assay anti–S-2P antibody geometric mean titer [GMT], 40,227 in the 25-μg group, 109,209 in the 100-μg group, and 213,526 in the 250-μg group). After the second vaccination, the titers increased (day 57 GMT, 299,751, 782,719, and 1,192,154, respectively). After the second vaccination, serum-neutralizing activity was detected by two methods in all participants evaluated, with values generally similar to those in the upper half of the distribution of a panel of control convalescent serum specimens. Solicited adverse events that occurred in more than half the participants included fatigue, chills, headache, myalgia, and pain at the injection site. Systemic adverse events were more common after the second vaccination, particularly with the highest dose, and three participants (21%) in the 250-μg dose group reported one or more severe adverse events.
CONCLUSIONS
The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified. These findings support further development of this vaccine. (Funded by the National Institute of Allergy and Infectious Diseases and others; mRNA-1273 ClinicalTrials.gov number, NCT04283461. opens in new tab)
I’m torn between excitement and the knowledge that a lot of Americans will either refuse to have it or possibly won’t be able to afford it.
Excited for the rest of y’all though.
Its sad for the children who will miss out because of moronic parents but I have little to no sympathy for adults who will succumb to their own ignorance.