DavidDeSchmikes
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- Jan 20, 2013
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There are two clinical trials of an AZ antibody cocktail underway in the UK at present.
The first a pre-infection mix that could do the job of a vaccine in people who vaccines are ineffective on (compromised immune systems)
https://www.nihr.ac.uk/news/uk-stud...razenecas-covid-19-antibody-combination/26275
The other a just-got-infected mix for people who've tested positive or who are at extremely high risk (vulnerable person in a household with someone who has tested positive) - but who aren't yet seriously ill (similar to the Trump situation)
https://news.sky.com/story/covid-19...nt-illness-in-those-recently-exposed-12172623
Trials of antibody mixes on people who are already seriously ill have basically stopped for now. Not enough evidence that they work - some suspicion that they might contribute to virus mutations in hospitalised patients.
https://www.gov.uk/government/publi...professionals-on-covid-19-vaccine-astrazeneca
The table at 5.1 is a bit unreadable..
The level of protection gained from a single dose of COVID-19 Vaccine AstraZeneca was assessed in an exploratory analysis that included participants who had received one dose. Participants were censored from the analysis at the earliest time point of when they received a second dose or at 12 weeks post dose 1. In this population, vaccine efficacy from 22 days post dose 1 was 73.00% (95% CI: 48.79; 85.76 [COVID-19 Vaccine AstraZeneca 12/7,998 vs control 44/7,982]).
https://assets.publishing.service.g...essionals_on_COVID-19_Vaccine_AstraZeneca.pdfFingers crossed!
This sounds pretty good:
The immunogenicity data does look promising on both fronts. 15x the number of antibodies 28 days after dose 1 vs unvaccinated folks, and 3-8x more for the second dose depending on the dosing wait time (longer = higher). From memory that’s a very healthy amount after the first dose even vs. a couple of vaccines already approved in China and Russia.
I am ignorant on this - does antibodies from a vaccine correlate to protection levels? Will the, say, the ones that contracted COVID in the test group have no or fewer antibodies?Fingers crossed!
This sounds pretty good:
The immunogenicity data does look promising on both fronts. 15x the number of antibodies 28 days after dose 1 vs unvaccinated folks, and 3-8x more for the second dose depending on the dosing wait time (longer = higher). From memory that’s a very healthy amount after the first dose even vs. a couple of vaccines already approved in China and Russia.
Based on published Phase1/2 studies - vaccinated people have more antibodies than people who've recently recovered from covid.I am ignorant on this - does antibodies from a vaccine correlate to protection levels? Will the, say, the ones that contracted COVID in the test group have no or fewer antibodies?
If someone gets vaccinated, can they take a test that determines whether the vaccine will protect them?
I am ignorant on this - does antibodies from a vaccine correlate to protection levels? Will the, say, the ones that contracted COVID in the test group have no or fewer antibodies?
If someone gets vaccinated, can they take a test that determines whether the vaccine will protect them?
Remember when @Pexbo joked we’d probably “only” manage 500k per week.
It is, but the rollout will need to be running well to get much above 5m/month. Plus it then goes to a quesion where do you want to draw the vulnerable line.I wonder what the numbers are for vulnerable population in the UK . If you can get say 10 million vaccinated by February then surely that's a huge proportion of clinically vulnerable already done
In pretty sure that violates the Hippocratic oath. There is talk of the possibility of hospitals having to prioritise treatment based on survival chances should they get overwhelmed (or young vs old, I can’t remember the specifics) but that’s a little different to tossing certain people to the back of the queue based on their beliefs or dissent towards a vaccine.Should the government start indicating to the general public that vaccination is voluntary but treatment, should they catch CV, will be weighted against them if hospitals are busy?
Or is this too Draconian?
I think the government definitely needs to do more to promote vaccination though , if FB is anything to go by then there is a big number of anti vaxxers even in the UK
If someone dont want to get vaccinated, they should be treated as anyone else if they got the coronavirus...but at their expense
there’s a part of me that agrees. But then you could expand that thinking to people who smoke, drink or are fat. All social issues.
I’m sure there will need to be some sore of anti-discrimination law at some point for vaccinations.
for example would you employ a care assistant in a nursing home who refuses to be vaccinated?
I thought the 1 dose thing was only for the Oxford vaccine; and even there they said that the 2nd dose would follow within 12 weeks?!
Edit - I’m wrong:
Based on Pfizer’s statement, they need to urgently clarify how they’ve decided to change the dosing regimen.
They could (almost but not quite as we can't bring the dead back) make up for their mistakes during this whole thing if they found a way to get this rollout done quickly and effectively but it looks like they're making a meal of even this.I try to be understanding and live my life as free as negative emotions as possible.
But my hatred of these twats honestly knows no bounds.
They could (almost but not quite as we can't bring the dead back) make up for their mistakes during this whole thing if they found a way to get this rollout done quickly and effectively but it looks like they're making a meal of even this.
At some point though we've got to get past being angry at Boris and co and look at the elephant in the room, i mean he didn't vote for himself did he?
I thought the 1 dose thing was only for the Oxford vaccine; and even there they said that the 2nd dose would follow within 12 weeks?!
Edit - I’m wrong:
Based on Pfizer’s statement, they need to urgently clarify how they’ve decided to change the dosing regimen.
Haha bad choice of words but you know what i meanProbably did to be fair. Can’t imagine him voting Labour
There’s a lot of different agendas at play here. Pfizer have a big financial incentive in ensuring that everyone gets two doses of their vaccine asap. I’ve no idea the basis for the decision to delay the second dose but it’s possible there’s science behind it.
There’s a lot of different agendas at play here. Pfizer have a big financial incentive in ensuring that everyone gets two doses of their vaccine asap. I’ve no idea the basis for the decision to delay the second dose but it’s possible there’s science behind it.
Among all participants (regardless of evidence of infection before or during the vaccination regimen), 50 cases of COVID-19 occurred after Dose 1 in the BNT162b2 group compared with 275 cases in the placebo group, indicating an estimated VE of 82% (95% CI: 75.6%, 86.9%) against confirmed COVID-19 occurring after Dose 1 of the 2-dose regimen, with VE of 52.4% (95% CI: 29.5%, 68.4%) between Dose 1 and Dose 2.
The early onset of protection is readily apparent from cumulative incidence curves, which show that disease onset tracks conjointly for BNT162b2 and placebo until approximately 14 days after Dose 1, at which point the curves diverge, with cases steadily accumulating in the placebo group, while remaining virtually flat in the BNT162b2 group.
So none of these vaccines have been approved for use in children. With kids getting such a mild illness the risk benefit of injecting them with novel vaccines just doesn’t add up. Hancock specifically stated today that there are no plans to vaccinate children in the UK. I can see them running trials in adolescents at some point but younger kids might never be vaccinated.
So what does this mean for the zero covid countries like Aus/NZ? Will they be vaccinating children? Will they be asking unvaccinated children of tourists to quarantine for the foreseeable future?
Or is the plan to vaccinate all the Aus/NZ adults then let the virus into the country to spread naturally through the children?
@Wibble
@Stacks
I thought the 1 dose thing was only for the Oxford vaccine; and even there they said that the 2nd dose would follow within 12 weeks?!
Edit - I’m wrong:
Based on Pfizer’s statement, they need to urgently clarify how they’ve decided to change the dosing regimen.