Pfizer and it must definitely be the vaccine because I'm still feeling so fecking tired.
The vaccines | vaxxed boosted unvaxxed? New poll
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I had a fever and was tired after my second dose of moderna. Two days later i was better.
Yep, I was reading those numbers earlier. It's remarkable just how different they look once you break them down into the age bands.
I'm still not sure what is really being observed on the vaccine efficacy waning stuff either. Preparing to use boosters on some risk groups sounds reasonable, but I think there may be confiding factors we're missing in the Israeli data that's being cited.
The title mades me think that I needed to drink more coffee. 
Sounds about right. I had mine on Sunday and was wiped Monday. Here we are on Wednesday and I'm still pretty tired.
No fever for me fortunately but just feeling pretty drained. Didn't experience any of this with the first dose.
My hope is that I'm perfectly fine for the weekend at least.
Pfizer
First dose: Felt like crap. Fever.
Second dose: Bit of a headache for one day, but nothing other than that.
First dose: Felt like crap. Fever.
Second dose: Bit of a headache for one day, but nothing other than that.
That's what the thread addresses. The confounding variable is age.
It's this graph that I keep seeing quoted on the booster issue.
I've seen the raw overall efficacy/efficiency number successfully dismantled by Chise and a couple of others now. It's that month by month thing that I've not seen the real numbers or background on.
My instincts say - they started with the oldest, the highest risk healthcare workers and the cities (likely the highest socialisation stats) hence the graph. But I've not seen the details - like month by month demographics etc.
I know a couple of Twitter people have suggested that the (more) unvaxxed groups in Israel are different to the (most) vaxxed. One element that's come up is with some less vaxxed orthodox groups, less socialising outside the community, and less travel etc.
It feels like the confounders could be important. The UK data may look different (and not just because it's a month or so behind).
Can we add a ‘Not going to have the vaccine for any reason’ to the poll? Would be interesting to hear some view points from those who don’t want it or can’t have it.
Effectively that's the ten years+ group. Anyone who's waiting for that long is planning on catching the SARS2 virus and hoping it doesn't hurt them or their friends, family, contacts.
I was Moderna and was 101.3F the next day. Lay in bed mostly.
I got out of bed but barely.
Whoops. Jamaica. Trying to get as many vaccinated as possible partially.This made me laugh more than it should. Twice Ramshock asked where and ….
Initially went well but not a major country so supplies delayed uptake. We're finally getting supplies in now to get to 50% or more by end of the year but there's not been enough dosages applied since end of July when supply was no longer a problem.
We're around 300k first and single doses but only around 140k fully vaxxed.
Population is around 3 million so way off the target we have which is 2 million by March and 1 million by October.
So we'll definitely be taking longer between doses. J & J is supposed to be at least half of that 1 million target though and that should be arriving by end of the month so we'll see what happens there.
€2k if you use one and 3 years if you're selling them.
Yup - I was discussing this with @Wibble and expecting FDA to reccomend a booster shot for the entire general population.
My 73yo mother had her 3rd jab yesterday (Astra Zeneca*). Apparently she was puking last night (She blames it on a cold beer she had at lunch) but feeling much better today.
Makes me feel good knowing she should be quite protected.
*The first two doses were Sinovac.
Makes me feel good knowing she should be quite protected.
*The first two doses were Sinovac.
Context
Most likely I won't take one for the time being as I already had COVID 5 months ago and still have antibodies. Probably next year, but will wait to see how each vaccine fares with the delta.
There's no shortage of vaccines otherwise.
I looks like Australia is planning a third Delta tweaked shot of Modena or Pfiser for everyone in 2022.
Your immunity will almost certainly be better if you are vaccinated now and you can still get a Delta tweaked shot when they are available.
Had my second shot the other day and have been pleasantly surprised that I suffered no side effects from neither that nor the first one, apart from a tiny bit of soreness in the arm.
More great stuff on vaccine efficacy from Denmark.
This is really interesting because while there are variations in the mRNA sequence the amino acid sequence, based on this, is identical for the 2 vaccines. I wonder if this is suggesting that Moderna's carrier method is more effective than Pfizers? They are both using lipids, and from what I have read they use some in common, so the few differences must be key. Can't wait to see the follow up papers on this.
there must be a substantial difference in vectors (right word?) given the different storage temps (-80, -20)
Not sure. I found this website breaking down the carrier and transport media compositions and there are some differences but they are both using the same idea (cationic lipid nanoparticles). I am guessing that the Moderna lipids may be more stable at the "lower" temp, either due to the lipds themselves or modifications to the transport media.
A Simple Breakdown of the Ingredients in the COVID Vaccines - COVID-19, Health Topics - Hackensack Meridian Health
Maybe it could be the does of vaccine given? The Moderna jab gives you 100 micrograms of vaccine compared to 30 micrograms with Phizer. There didn't appear to be much effect from that, but possibly it's showing its effect over time.
Observational data is notoriously bad at identifying “real” differences between treatments. Loads of confounding variables. Especially in a scenario like this where one intervention was used much more often than the other (Pfizer doses vastly out-number Moderna throughout the EU)
My only take home from this would be that both vaccines give excellent protection rather than wondering if one vaccine is better than the other.
Having my 2nd dose of Pfizer this morning. Had no symptoms except a sore arm for a day after my first dose.
Some more data coming from a large UK study. It is adding to the data that AZ seems to keep its effectiveness over a longer period of time, but the mRNA vaccines are more effective immediately so the drop-off makes them around the same level as AZ after 5 months.
It again shows how effective all the vaccines are and how well they are holding up in the UK against Delta.
https://www.ndm.ox.ac.uk/covid-19/covid-19-infection-survey/results/new-studies
It again shows how effective all the vaccines are and how well they are holding up in the UK against Delta.
https://www.ndm.ox.ac.uk/covid-19/covid-19-infection-survey/results/new-studies
Just had my second dose of AZ(Covishield in India) two days ago. No symptoms at all.
Now 53.8. Only just realised there was a poll.
Some reassuring data from vaccine effectiveness against delta. It seems that timing of the doses really is key to longer lasting protection and a booster dose to the most vulnerable seems the right way to go.
It's because the cafe is full of old farts. The number is probably higher but one of the things about being old is your memory doesn't work as well. I only just remembered I had both doses by June but have only remembered to update the poll. I've moved it up to 54% now.
Guiltily as chargedIt's because the cafe is full of old farts. The number is probably higher but one of the things about being old is your memory doesn't work as well. I only just remembered I had both doses by June but have only remembered to update the poll. I've moved it up to 54% now.
Not really; I’d simply avoided the thread because I doubted whether it was a place for reasonable discourse.
Had my second dose of Moderna on Monday. Was told by the other half to take some paracetamol before bed but because I’m an absolute machine I didn’t bother. Anyway, came home from work at break time the next day as I was all over the place. Loads of ibuprofen and a nap and I was fine the day after.
Pretty glad all in all. Convinced I had a really weird side effect after the first dose but no repeat of that.
Pretty glad all in all. Convinced I had a really weird side effect after the first dose but no repeat of that.
No doubt this is the case, but everything I have ready suggests there is a real difference in the immunity provided by the 2 vaccines. There have been a few small scale studies looking at differences in IgG levels (GMT) and ID50's. Moderna does seem to produce higher GMT's, but it's hard to know if that is real without a large scale controlled study. That's what I meant by being excited about the follow up papers. Hopefully the lessons learned will help in the design of the second generation of mRNA vaccines,
Moderna
First dose, arm wrecked for a few days but felt fine ltherwise
Second dose, ill for two days then a banging headache for a couple of days after that
Glad they’re done.
First dose, arm wrecked for a few days but felt fine ltherwise
Second dose, ill for two days then a banging headache for a couple of days after that
Glad they’re done.
The study I linked earlier also suggests similar.
- A single dose of the Moderna vaccine has similar or greater effectiveness against the Delta variant as single doses of the other vaccines.
https://www.ndm.ox.ac.uk/covid-19/covid-19-infection-survey/results/new-studies