Lennon's out, I think. So that's a good thing. ....
Lennon isn't out. He played and scored yesterday.
I think the Spurs team will be lined up in a 4-4-2 as follows:
---------------- Lloris
Walker - Dawson - Chiriches - Rose
Lennon - Paulinho - Dembele - Eriksen
----------- Soldado - Adebayor
Games between Spurs and United are usually very open, but this one will be even more so ... both because I expect Sherwood to continue with his emphasis on attack and basically aim to score more goals than you do, and also because I expect him to play without a recognised DM (this assumes that Paulinho will be fit, despite coming off with an injury yesterday).
Eriksen will only play nominally on the left, so at any given time Paulinho, Dembele and Eriksen might be found mostly in almost any position in CM, defensive or attacking. This will give you greater scope for attacking down our left flank, but will also increase the attacking pressure from Spurs on your back four.
I think that both back fours will come under a lot more pressure than usual: ours because of not playing with a recognised DM and offering a weakened left flank, yours because it will have two strikers to cope with, supported by a very attacking central midfield.