SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

Just to update, after two days of nasty symptoms and extremely poor sleep, I slept for twelve hours last night uninterrupted (which is practically unheard of for me), and now feel tonnes better. Hope you’ve seen a similar improvement!
Same - last two nights I've slept for 10 hrs + and I feel just so much better. Not ready to bike a century yet, but I may be able to carry a few grocery bags for a few blocks without panting
 
Posting this not necessarily as an endorsement, but I think many are coming around to this point of view right now (note he is a UCL professor who, according to Wikipedia, “led the first large-scale sequencing project of the Sars-CoV2 genome”):






I'm no expert but that's what it looks like to me as well. It's looking like a mild enough version now that we can go ahead and get it.

That being said, due to the trauma caused by this pandemic I expect the response to be conservative, and to treat this variant as if it were more dangerous just to be better prepared in case he and I are wrong. With so much at stake it makes sense people would err on the side of caution here.
 
Posting this not necessarily as an endorsement, but I think many are coming around to this point of view right now (note he is a UCL professor who, according to Wikipedia, “led the first large-scale sequencing project of the Sars-CoV2 genome”):







@Pogue Mahone @jojojo @africanspur Do you know which drugs he is talking about for treatment?
 
@Pogue Mahone @jojojo @africanspur Do you know which drugs he is talking about for treatment?
The new ones for treating people to stop it getting serious are Paxlovid & Monulpiravir. Paxlovid did very well on clinical trial. Budesonide (an asthma drug) and some others that have done well on trials are around as well, but I'm not sure if they're being routinely prescribed anywhere.

I believe the NY mayor has just announced they've got Paxlovid available, but then I read a NY doctor say that in reality they have only a limited number of doses available. I really don't think the supply is there for mass prescribing.

I'm guessing what you're asking is what's available now, but I suspect that comes down to your exact location and your doctor, and whether he can get treatments through early availability and rollout trial programs.
 
So there's a drug now to save the anti vaxxers should things go south. I wonder if the ironing will be lost on them?
 
The new ones for treating people to stop it getting serious are Paxlovid & Monulpiravir. Paxlovid did very well on clinical trial. Budesonide (an asthma drug) and some others that have done well on trials are around as well, but I'm not sure if they're being routinely prescribed anywhere.

I believe the NY mayor has just announced they've got Paxlovid available, but then I read a NY doctor say that in reality they have only a limited number of doses available. I really don't think the supply is there for mass prescribing.

I'm guessing what you're asking is what's available now, but I suspect that comes down to your exact location and your doctor, and whether he can get treatments through early availability and rollout trial programs.
Forgot to say there's also a monoclonal antibody treatment called sotrovimab that works against omicron, but I think the other monoclonals look like they won't help.

All the drugs come with lots of provisos, particularly about things like interactions with other medications and safety when used by people with certain medical conditions. I don't think any of them are at the stage where they can be prescribed routinely.
 
The new ones for treating people to stop it getting serious are Paxlovid & Monulpiravir. Paxlovid did very well on clinical trial. Budesonide (an asthma drug) and some others that have done well on trials are around as well, but I'm not sure if they're being routinely prescribed anywhere.

I believe the NY mayor has just announced they've got Paxlovid available, but then I read a NY doctor say that in reality they have only a limited number of doses available. I really don't think the supply is there for mass prescribing.

I'm guessing what you're asking is what's available now, but I suspect that comes down to your exact location and your doctor, and whether he can get treatments through early availability and rollout trial programs.

Thanks, I appreciate that. One of my relatives, from New York actually, had it two months ago (so maybe it was Delta) and she had severe symptoms. Her GP prescribed her something that really helped in like 2-3 days. I wonder if it was one of those, but I haven't heard yet what it might have been.
 
So there's a drug now to save the anti vaxxers should things go south. I wonder if the ironing will be lost on them?

What's this? Just asking because my parents have turned to anti vaxxers at an old age and I'm keeping updated due to me being worried.
 
Just before the advent of covid, or when it became a thing for us in UK me and one of my son's ended up in hospital due to breathing difficulties. Basically I was breathing like Darth Vader and my son was similar. We had xrays etc done and we're prescribed a drug which cleared it up within a few days. It was suspected pneumonia but never diagnosed as that in the end.

I'm talking a good 4-6 months before Wuhan became a thing. I have no under lying. Conditions (eg asthma) neither has my son.

Never thought about it much at the time. One of those "I was ill and it got sorted" moments.

Thinking back I've often wondered if it was in anyway covid related.
 
Just before the advent of covid, or when it became a thing for us in UK me and one of my son's ended up in hospital due to breathing difficulties. Basically I was breathing like Darth Vader and my son was similar. We had xrays etc done and we're prescribed a drug which cleared it up within a few days. It was suspected pneumonia but never diagnosed as that in the end.

I'm talking a good 4-6 months before Wuhan became a thing. I have no under lying. Conditions (eg asthma) neither has my son.

Never thought about it much at the time. One of those "I was ill and it got sorted" moments.

Thinking back I've often wondered if it was in anyway covid related.
If it was two of you, months before the actual start of the covid pandemic, you would have spread it across the entire community in a matter of weeks. Then evidence of the virus would have been found months earlier and hospital death rates would have noticeably spiked for anyone in the media to see (since it's all visible on the NHS website).

Which is to say, I doubt you were in the covid vanguard. It's not a disease that hides in the shadows waiting for the right moment pounce. If you'd had it that far in the past, the whole pandemic would have also started that far in the past. Track-and-trace from March or April 2020 shows that it didn't.

I think genome sequencing also shows that the trail of mutations all lead back to a granddaddy version in Wuhan December 2019. There's nothing to suggest there was a second early origin point in the UK.

So don't blame yourselves for anything. It wasn't your fault. I say that assuming you and your lad never bought some Kentucky Fried Pangolin in China around about that time.
 
If it was two of you, months before the actual start of the covid pandemic, you would have spread it across the entire community in a matter of weeks. Then evidence of the virus would have been found months earlier and hospital death rates would have noticeably spiked for anyone in the media to see (since it's all visible on the NHS website).

Which is to say, I doubt you were in the covid vanguard. It's not a disease that hides in the shadows waiting for the right moment pounce. If you'd had it that far in the past, the whole pandemic would have also started that far in the past. Track-and-trace from March or April 2020 shows that it didn't.

I think genome sequencing also shows that the trail of mutations all lead back to a granddaddy version in Wuhan December 2019. There's nothing to suggest there was a second early origin point in the UK.

So don't blame yourselves for anything. It wasn't your fault. I say that assuming you and your lad never bought some Kentucky Fried Pangolin in China around about that time.


At the time there had also been some news from the USA about people dying and being hospitalized with breathing difficulties or surviving but now 20 year olds having lungs of 70 year olds.

Think it was something to do with vaping and mixing liquids, or so the conclusion went.

I wasn't vaping and my son was very young. We were a big family and no one else has any symptoms similar to ours.

I did get covid about 8 months back. I've had colds that were worse. A couple of days of shivering and a slight cough and fever. My dad same. Other members got it even more mildly
 
I'm no expert but that's what it looks like to me as well. It's looking like a mild enough version now that we can go ahead and get it.

That being said, due to the trauma caused by this pandemic I expect the response to be conservative, and to treat this variant as if it were more dangerous just to be better prepared in case he and I are wrong. With so much at stake it makes sense people would err on the side of caution here.

A lot of companies in the US are erring on the side of wanton carelessness. Some businesses I know of are forcing people to come into work unless they are symptomatic with a fever which seems insane to me when their jobs could be 100% done working from home. What I'm hearing from one workplace, even if people are positive and symptomatic, the boss expects them to come into work which is truly fecking insane. Even here in California, the state and city officials aren't issuing the safer from home mandates they did a year ago despite skyrocketing new cases.
 
“If the self-isolation rules are what’s making the pain associated with Covid, then we need to do that perhaps sooner rather than later. Maybe not quite just yet.

“Covid is only one virus of a family of coronaviruses, and the other coronaviruses throw off new variants typically every year or so, and that’s almost certainly what’s going to happen with Covid. It will become effectively just another cause of the common cold.

“Once we’re past Easter, perhaps, then maybe we should start to look at scaling back, depending on, of course, what the disease is at that time.”
Grauniad

We may be nearing the tipping point where the restrictions cause more problems than virus itself.

Still a little ways to go before anyone can say for certain, though. Scientists will need to see the data from the Christmas period aftermath before they reach any reasonable conclusions.

The guy in the article is suggesting Easter as a possibility. Personally, I think hotspots like London and New York will get there a lot sooner. Maybe that's just wishful thinking.
 
Could this be over soon?

Is there a chance that omicron will ultimately be the final obstacle / notable variant and that we would really move on from all of this after the next few weeks?

Really at my wits end
 
Could this be over soon?

Is there a chance that omicron will ultimately be the final obstacle / notable variant and that we would really move on from all of this after the next few weeks?

Really at my wits end
There's a chance, yes.

Nobody with a reputation to uphold would ever say so. Thankfully, I don't have one.
 
What’s to say there won’t be tonnes of similar variants though?

Genuine question as I’m not sure.
There might be.

It's worth remembering that covid-19 is not the only coronavirus in the world. In fact, 15% of common colds are caused by other kinds of coronavirus. Those other kinds of coronavirus also mutate. But as you'll have experienced yourself, people can generally cope with those mutations because they've retained immunity from similar variants in the past.

What made covid-19 so dangerous was the the lack of pre-existing immunity in the population. But the entire world (pretty much) is going to have some level of immunity quite soon - either from vaccines or from prior infection (with vaccines giving the best long term protection).

For the next variants to continue to cause concern, they'd need to be able to evade that immunity. Two vaccines seemed to be good at that all the way up to the delta wave. Omicron was a bit of a spanner in the works because of how different it was (apparently it emerged after somebody caught delta and the common cold at the same time and the two genomes got merged together). But the fact that 3 shots of a vaccine originally designed to beat alpha has now been proven to also deal with everything from beta to delta to omicron makes me hopeful of our immunities' long term effectiveness against any later variants.

I don't know any of this for sure, of course. Like I said earlier, there must have been a healthy dose of wishful thinking mixed in with my Pfizer. And I'm a glass half full kind of guy.
 
Still just a standard dose of man flu here with me after testing positive Xmas day.


Did you get a PCR test yet? Just tested positive after taking a lateral flow test been feeling iffy since yesterday.

Will try again tomorrow for a PCR test as nearest one there now was in Antrim 55 miles away and I'm not doing that
 
Did you get a PCR test yet? Just tested positive after taking a lateral flow test been feeling iffy since yesterday.

Will try again tomorrow for a PCR test as nearest one there now was in Antrim 55 miles away and I'm not doing that

I wouldn’t bother with a PCR. Assume you have covid and act accordingly. The test capacity is completely overwhelmed and you’ll learn nothing useful anyway.
 
I wouldn’t bother with a PCR. Assume you have covid and act accordingly. The test capacity is completely overwhelmed and you’ll learn nothing useful anyway.

Yeah I guess can't believe I got it as I try and be so careful this one must be really contagious.

Hopefully won't feel to bad as I have gotten the booster.
 
There might be.

It's worth remembering that covid-19 is not the only coronavirus in the world. In fact, 15% of common colds are caused by other kinds of coronavirus. Those other kinds of coronavirus also mutate. But as you'll have experienced yourself, people can generally cope with those mutations because they've retained immunity from similar variants in the past.

What made covid-19 so dangerous was the the lack of pre-existing immunity in the population. But the entire world (pretty much) is going to have some level of immunity quite soon - either from vaccines or from prior infection (with vaccines giving the best long term protection).

For the next variants to continue to cause concern, they'd need to be able to evade that immunity. Two vaccines seemed to be good at that all the way up to the delta wave. Omicron was a bit of a spanner in the works because of how different it was (apparently it emerged after somebody caught delta and the common cold at the same time and the two genomes got merged together). But the fact that 3 shots of a vaccine originally designed to beat alpha has now been proven to also deal with everything from beta to delta to omicron makes me hopeful of our immunities' long term effectiveness against any later variants.

I don't know any of this for sure, of course. Like I said earlier, there must have been a healthy dose of wishful thinking mixed in with my Pfizer. And I'm a glass half full kind of guy.
Thanks for the detailed reply. Hopefully the differences that made Omicrom variant dangerous aren’t as easily repeatable going forward.
 
It’s insanely contagious. We’re all gonna catch it soon enough. You’ll be grand, I’m sure.
I’d love if someone crunched the potential numbers in Ireland. Feels like at the rate it’s currently spreading everyone who can get it will by the end of January! What happens then? Do we let it run riot in the hope that finishes things for good or do we have to do a proper lockdown again first?
 
Did you get a PCR test yet? Just tested positive after taking a lateral flow test been feeling iffy since yesterday.

Will try again tomorrow for a PCR test as nearest one there now was in Antrim 55 miles away and I'm not doing that
Yea got one in omagh on boxing day. Kept checking back every few hours and then they released the following days times. They're filling up fast.

Hope it doesn't get to bad for you.
 
I’d love if someone crunched the potential numbers in Ireland. Feels like at the rate it’s currently spreading everyone who can get it will by the end of January! What happens then? Do we let it run riot in the hope that finishes things for good or do we have to do a proper lockdown again first?

I think it will run riot like you say, then cases will ease off again and we’ll get through this wave without ever doing “a proper lockdown”. The boosters will do the trick and it’s a less virulent strain anyway. Our hospitals will cope.
 
I’ve been feeling progressively worse since yesterday. Scratchy throat, mild aches, heavy head. Not sure if I have it or not. Son should have his PCR result tomorrow. I’ve not taken mine yet. He is feeling better and I’m feeling worse. No one else in house is sick.

I’m not sure how but I think he dodged a bullet not catching it from his GF but managed to bring some other crud with him. Unless the tests just aren’t accurate for us for some reason. This will be the 3rd time I’ve had negative tests since this whole thing started last year. Each time I’ve been sick too. First two times I had fever and was knocked on my ass for 3-4 days and I never get sick. I know Covid generally lasts longer so must have been the flu or a bad viral infection.
 
I think it will run riot like you say, then cases will ease off again and we’ll get through this wave without ever doing “a proper lockdown”. The boosters will do the trick and it’s a less virulent strain anyway. Our hospitals will cope.
Who are you and what have you done with Pogue?!?

I hope you’re right, that’s my gut feeling too but my knowledge is far more limited.
 
Who are you and what have you done with Pogue?!?

I hope you’re right, that’s my gut feeling too but my knowledge is far more limited.

It’s been the exact trend in SA, Denmark and now London. The pessimists are determined to keep arguing you can’t assume what happens in one country will happen in another but when the same pattern repeats in three different countries…

I’m finding this current phase really strange. The expert opinions have got more tribal and divided than ever. It actually feels like the loudest voices crying caution don’t actually want the pandemic to end.
 
It’s been the exact trend in SA, Denmark and now London. The pessimists are determined to keep arguing you can’t assume what happens in one country will happen in another but when the same pattern repeats in three different countries…

I’m finding this current phase really strange. The expert opinions have got more tribal and divided than ever. It actually feels like the loudest voices crying caution don’t actually want the pandemic to end.
There are a lot of people who don’t want Covid to end. The idea of life going back to normal upends a lot of the good things that have come out of the last two years for them like WFH and less social obligations. Not saying that applies to the experts you refer to but it’s definitely a thing. It’s even evident in this thread with people crying out for lockdowns as soon as they see record numbers in the news or what not.
 
Well, other than my running nose I'm feeling alot better now, Xmas day was the worst though. Cold then hot, constant headache, tiredness followed by the weirdest dream.
 
It’s been the exact trend in SA, Denmark and now London. The pessimists are determined to keep arguing you can’t assume what happens in one country will happen in another but when the same pattern repeats in three different countries…

I’m finding this current phase really strange. The expert opinions have got more tribal and divided than ever. It actually feels like the loudest voices crying caution don’t actually want the pandemic to end.
I agree with you though I would caution that the only remaining unknown is what happens when cases take off in the older age groups. We didn’t really get that in SA and it started increasing later in the over 60s in London so we should find out what impact that has on hospitalisations in the next few days - this age group had boosters first. However, we have a scientific basis for why it would be less virulent, the data is showing it’s less virulent (no real increase in ITU beds in London, proportion of incidental COVID admissions increasing) and it is displacing delta - I don’t really get the argument for tougher restrictions at this point outside of stopping such a high percentage of the country being off work simultaneously.
 
Well, other than my running nose I'm feeling alot better now, Xmas day was the worst though. Cold then hot, constant headache, tiredness followed by the weirdest dream.


Yeah boxing Day was probably the start of it for me should have tested then but I'm diabetic and thought it was a hypo as felt similar headache really tired just couldn't function and slept the day away though bloods were fine which looking back should have tipped me of.



Now it's like a cold just nose constantly running but other than that feel ok.

Hopefully that will stop in a day or two