Ok, fair enough. I do see your point about 5% vs 15% being kind of meaningless.
The vaccines | vaxxed boosted unvaxxed? New poll
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In the latest episode of the United Hour Podcast, Nik (@Rood) is joined by CEO Duncan Drasdo and Financial Director Andy Green from the Manchester United Supporters Trust for a special episode on all things behind the scenes at Old Trafford including a brief history of MUST and their aims today, views on INEOS and Sir Jim Ratcliffe so far, and the Old Trafford regeneration.
Ok, fair enough. I do see your point about 5% vs 15% being kind of meaningless.
Just had my first dose Oxford next one 24th April. So far so good no effects.
Don't see why anyone would not want the vaccine
Don't see why anyone would not want the vaccine
I doubt Russia and China have shipped anywhere close to 800m doses. They may well have promised 800m doses though and they may well be doing better than the US/UK/EU at shipping even the few million doses that have been requested by Covax/GAVI and WHO for urgent use (for health care workers and the like). The doubts around AZ have left a big hole in what's available through those organisations as well.
There are lots of other "coming soon" vaccines, that have early doses committed to supply high risk countries like SA and Brazil, but haven't done so far. In particular J&J/Janssen may be ready to ship millions of doses soon but won't reach high volume until later in Q2. Novavax have a GAVI order for 1.1B doses, but realistically won't have many doses available until Q3.
It's also worth looking at the deaths/cases stats. It's still the case that Europe and the US have the worst numbers - a situation that's partly but not solely down to testing/reporting rates. In this context it's very questionable that (for example) Australia and New Zealand "need" more than a few thousand vaccines at this stage (to cover quarantine hotel/airport staff etc)
India has some of the biggest vaccine manufacturers in the world, and own plant in Europe as well. They're currently producing far more Oxford/AZ than AZ themselves can produce. They'll also produce the majority of Novavax doses and some other vaccines.
The vaccine business has been mostly either low volume or low profit for many years. There was more or less no bulk manufacturing capacity in the UK prior to covid, and a large proportion of Europe's plant had been mothballed or repurposed. The effective removal of the US plants from the global supply chain has left the UK and Europe scrambling for capacity. It's fair to say that this will have come as quite a culture shock for governments who've happily seen manufacturing industry decline because the "world market" could supply it cheaper.
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Efficacy of CoronaVac in elderly has a 95% confidence interval of -166% to 91%. This report is worse than those submitted by bachelor students.
https://bit.ly/3uhLQxG
https://bit.ly/3uhLQxG
I need some help guys. My mum got the first dose of Pfizer the Wednesday before last (11 days ago). Since the next day until this current moment, she’s been feeling like complete shit with a high fever, extreme fatigue, occasional chills, and now a cough. She has no underlying health conditions and is in her early 60’s. We got her tested for Covid just in case a couple of days ago and it came back negative. Why is this going on for 11 days now? What could it be? If it isn’t Covid and I haven’t heard of anyone having a reaction for this long after the jab. We’ve been to the doc twice, they did some checks on her (oxygen, etc) and said everything was fine, and that she should wait a bit and come back if it persists. She’s going into her 2nd week of this now and I’m worried that it might not be the type of thing where you should just tough it out, and I don’t want things to deteriorate. Any ideas would be much appreciated.
Nothing wrong with the report. Those confidence intervals are just a consequence of low numbers of elderly people in the study. Just 400 out of 12000 recruited. When your end point is grossly under-powered, a very wide CI is inevitable. Same issue as with the AZ vaccine. Early phase data indicates it should work in the elderly but hasn’t yet been confirmed in a Phase 3 study because they didn’t recruit enough elderly subjects.
I presume this will be resolved in the same way the AZ issue will. Ongoing recruitment of older subjects will hopefully eventually generally statistically significant results in that cohort.
Nothing you can do but keep an eye on her and keep in contact with your doctor. They simply don't know the full details of all side effects of the vaccine, as I've posted already about the side effects my mum had. Everyone reacts differently, you just hope you don't get the worst side effects.
Visit another doc.
Not saying it's wrong, just that the quality is shocking. I'm not familiar with AZ, but this report is basically meaningless and gives no indiction even with the adult age group. You can neither recommend for or against this vaccine based on this report.
As far as I know, they have no intention in completing a proper Phase 3 study, let alone recruiting more elderly subjects. Their only concern is to ship as many vaccines to Africa as possible.
Could be another virus like flu maybe? As someone else said - go to another doctor.
The data for the oldest cohort isn't meaningful. Sample size is far too small.
What test did she do, lateral flow or PCR? If it's the rapid flow ones.. Like the 30min result ones then they aren't as accurate as where you send it off for a result.
If she has covid then the good news is she's entering her second week with stable oxygen levels, so it's hopefully pointing to a non severe bout (whether it's covid or flu).
For context my mum and dad got covid 5 days after their vaccine. Dad was mild, mum was a bit worse than how your mum was feeling (from how it reads). My mum had zero energy and strength but stable oxygen. She needed a drip for energy but, She got through fine after closing in on week 3.
Fluids are massive, my mum needed a saline drip but then turned a corner from that alone and went stronger and stronger.
If your mum has very little energy just keep at it with fluids and electrolytes? Also try and have her walk a bit just as practise as uti can be common when you're hit with a bad flu. Her oxygen being stable is good, but for peace of mind buy an oxidiser so you can monitor at home too.
Bigger picture, stable oxygen is very good. Hopefully it's just a bad flu to overcome. If it's covid then hopefully it's just a normal bout of it. It's pointing to it not being serious so hope that continues.
next lines explain it:
Makes sense given that their phase 3 was Brazilian healthcare workers (Pg. 9 of the report)
The first Phizer jab was done today and #scottyfrommarketing had his shortly afterwards. We have 142,000 doses and 50,000 of those are being split between the states (who are responsible for administering them) with quarantine and front line health staff generally going first. I think much of the balance is being held in reserve in case of supply issues so that they can be sure they have the second dose available if there are issues. Theoretically we are getting a few deliveries of 100k+ doses rising 1 million doses a month from Phizer from April onwards but I suspect those dates may not be that firm. The AZ vaccine is being made here and should be online by the end of March at a rate of 1 million doses per week. The aim is to get every adult vaccinated by October. There is talk of assisting the region to get vaccinated so I can see us starting to do that by mid year if all the supplies we have ordered come through as we won't need them and opening the region up is economically (and ethically) important.
That's why I say the quality is poor. If you want to conduct a proper Phase 3 study, you won't select such a small sample size and later find out it is insufficient. The efficacy in adult age group (50.66%, 95% CI 35.75%-62.11%) is also barely acceptable. The study is crudely performed and the data are not even publicly published in a peer-reviewed journal.
I believe the other manufacturers didn't publish until after they got approval as well. (Pfizer published their phase 3 paper on Dec 31, Moderna this month, both were approved early December). The only ones who published before approval seem to be Oxford.
The rest of the data isn't that good, as you say, but in terms of phase 3 trials it is quite common that very old, very young and pregnant people are hugely underepresented. So not a criticism that is due to the current circumstances but rather a criticism of trials in general.
I wouldn't call people over 60 "very old". They are the vulnerable in the society and the target recipients of the vaccines. If you can't show efficacy in this group, your study is basically meaningless (especially when the efficacy in adult age group is also poor). For Pfizer they have ~15000 subjects over 55 (efficacy 80.6%-98.8%) and ~7700 subjects over 65 (efficacy 66.7%-99.9%); for Moderna they have ~7000 subjects over 65 (efficacy 61.4%-95.2%). You may still consider as an underrepresentation but at least the figures look much better.
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I'm not disagreeing with you and I think that older people need to be included in drug and vaccine trials far more than they currently are especially as our immune systems change as we age.
On the available data I can't see how you could approve use for the over 60's and it will be interesting to see if the rest of the data is good enough for approval.
Unfortunately our corrupted government is approving this vaccine for political reason, and they insist it is useful in elderly. Together with massive propaganda campaign, many in the society believe CoronaVac is safer and more effective than the Pfizer one.
OK so 3 days after the jab, no side effects. Arm around jab site is fine. I have been warned the reaction to the second jab is worse but as I said I've had far far worse reactions to flu virus's.
Without any facts to back this up other than first hand stories and stories I read, the random nature of the virus is what makes it particularly dangerous. You could be fit as a fiddle and end up in ICU.
im sure one of the many docs on here could answer better
Day after for me and feel like crap today like a really bad hangover head banging stomach sick and arm sore but small price to pay i suppose
Some initial signs from Scotland of a very positive impact of all the vaccines on hospital admissions. https://www.bbc.co.uk/news/health-56153600
Would be interesting to see how much data this is based on, but the AZ vax seems to be better than "quasi-ineffective" so far.
Would be interesting to see how much data this is based on, but the AZ vax seems to be better than "quasi-ineffective" so far.
Very very strange virus alright. Know of a fella in his early 40’s fit as a flea who ended up dying after catching covid, by the same token know of plenty over 70 who wouldnt know the meaning of exercise or a healthy lifestyle who had nothing more than a mild cold.
Exactly, that’s the scary nature off it. Precisely why I’m taking no chances
Had the second dose of the pzifer vaccine on Saturday. Honestly floored me on Sunday but over it now.
Had no reaction at all to the first one bar a sore arm at the injection site.
Had no reaction at all to the first one bar a sore arm at the injection site.
Took mine on Saturday. Feeling the full brunt of the side effects but luckily I’m not one of those conspiracy theorists that thinks it means I’m growing an extra arm or they’ve put radiation in it 
Some promising news coming from Scotland trials today i think?
Took mine on Saturday. Feeling the full brunt of the side effects but luckily I’m not one of those conspiracy theorists that thinks it means I’m growing an extra arm or they’ve put radiation in it
I'd love an extra arm tbh
Took me a while to find the actual publication but this looks like fantastic news. Fair play to the Scottish health service and their electronic health records. Would be a much more difficult study to do in most other countries.
Well with the way I’ve been more or less bed ridden and my joints aching since Saturday night I could also use an extra arm
Dr Octopus
Saw this in my news feed.
karnataka: Two hospitalised over rare disorder days after taking jab
there was another article.. from Himachal.. (different state.. way to the north of India)
‘Himachal health worker’s death not due to jab’
So 2 separate articles of 3 people.. in a couple of days...
No clue what GBS is.. How rare is it?
karnataka: Two hospitalised over rare disorder days after taking jab
so I googled to see if there was any more coverage of it.
there was another article.. from Himachal.. (different state.. way to the north of India)
‘Himachal health worker’s death not due to jab’
So 2 separate articles of 3 people.. in a couple of days...
No clue what GBS is.. How rare is it?
Arm still hurts. Bill Gates is a cnut.
Well with the way I’ve been more or less bed ridden and my joints aching since Saturday night I could also use an extra arm
That bad huh? My aunt got the Pfizer she's been sick ever since too. Guess that means the vaccine is working.
I remember reading somewhere that if you get sick after the first shot chances are you've had the rona. I think it was about the AZ vaccine, not sure if the same applies to Pfizer as well.
From experience, seemingly pretty rare. When a family member of mine was in hospital, the doctors thought he had it and half the doctors in the place came down to see him as a live GBS case. Was a complete merry-go-round.
My girlfriend had her vaccine yesterday morning. Was fine yesterday, though woke up feeling rough and has been vomiting this morning. Any advice on the best thing to do/ get her to ease the symptoms?