The vaccines | vaxxed boosted unvaxxed? New poll

How's your immunity looking? Had covid - vote twice - vax status and then again for infection status

  • Vaxxed but no booster

  • Boostered

  • Still waiting in queue for first vaccine dose

  • Won't get vaxxed (unless I have to for travel/work etc)

  • Past infection with covid + I've been vaccinated

  • Past infection with covid - I've not been vaccinated

Results are only viewable after voting.
jojojo said:
It's an interim report but it's got what looks like the most useful (to outsiders) data in it.

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia - The Lancet

And the appendices:
mmc1.pdf (thelancet.com)
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Cool. Very little to nit-pick there (other than lowish number of subjects). A well designed, well executed study. Using a different adenovirus for second dose makes a lot of sense and might explain excellent efficacy. These are arguably the most impressive results to date.

Also worth noting they’ve had a freeze dried version already approved in Russia. Storage at 2-8C.
 
I always had my money on Russia saving the world from the virus.
 
MikeUpNorth said:
I always had my money on Russia saving the world from the virus.
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As I just said on the main thread, this is following all the disaster movie tropes. Just when the end of our ordeal is in sight... Boom! Vaccine resistant new variant!

Makes sense that the eventual saviour would be another plot twist.
 
That's really good news about Sputnik V. It's cheap easy to store and unless anyone finds something hidden in the papers is high efficacy.

It sounds like the ideal candidate for a global roll-out on face value so let's hope.
 
Nothing about the Sputnik V vaccine news in my Google News feed. Weird.
Reading about it here though it looks really good.
 
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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Good luck Penna.
And yes, with more time passing (variants aside) the more uncommon side effects and risks of the vaccines should be known.
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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All the best Penna, hope everything works out for you x
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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I wouldn't know who to believe at the moment. Lombardy today said they should be able to do the whole region by June, and we have brought the start date for over 80s forward by a month. You might find that date comes forward.
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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That sounds hopeful. All the best with it.
 
lynchie said:
Some good news from Oxford/AZ - good protection (~76%) from three weeks after first jab. Also, PCR tests of people who had 2 jabs suggest 50% reduction in transmission.

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3777268
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That's another good news story and we need some of those. I suspect it's going to irritate a many people as it pleases, given that we're getting another efficacy result that appears to make a different dosing regime (in this case a single dose!) work better than the intended two dose pattern. It's certainly going to meet a lot of scepticism and cynical responses.

There is a self-consistent theory on why halfdose/full dose and now full dose/delay/full dose or the new joker in the pack AZ followed by Sputnik might work better than a 3-4 week interval - basically around the idea that the body can get keener on developing antibodies to the adenovirus than the spike.

I've not read the full thing properly yet, and I know the number of people involved is low (and the demographics are likely to be unrepresentative) so I'm currently reading it as wonderful if it gets borne out in the field rather than proven. Promising stuff though and good news for the UK vaccination program (though I'm sure it's exactly the kind of data that the MHRA were looking at when they authorised the 12 week interval)
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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Good stuff. By the time May comes round there will have been millions of vaccinations with whatever version you're offered, if there have been no problems similar to the ones you had all those years ago it will be looking good. You will have to keep safe meanwhile though, even if restrictions are reduced for everyone else.
 
711 said:
Good stuff. By the time May comes round there will have been millions of vaccinations with whatever version you're offered, if there have been no problems similar to the ones you had all those years ago it will be looking good. You will have to keep safe meanwhile though, even if restrictions are reduced for everyone else.
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I'm thinking the same, fingers crossed. :)
 
Penna said:
I said I'd update after I'd talked to a neurologist, in view of my autoimmune conditions and history of a previous serious reaction to a vaccination. His view (and he was elderly, so he's been around a long time) was that if I were offered the vaccine today, I should have it.

His view was that it would be more dangerous for me to catch Covid than to have the vaccine. He also said that it's being given to people with MS with no problems. Anyway, he's having his own second jab at the weekend and he's going to talk to the hospital doctors for me. I'm going back next Monday to see what they said.

Hope this helps anyone else who has similar issues and concerns. The neurologist did say that as time goes by, we'll all know more of course and because of the delays in vaccine supplies here in Italy, I won't be offered a vaccine until May in all likelihood. So there's time for more data to appear.
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Yes it does help so thanks for sharing. And best of luck with the jab.
 
Mickeza said:
Wonder what they are going to use to rollout to 80 plus, the shielding and care homes. Logistically Pfizer is a nightmare which is why we’ve let the GPs with Oxford handle them.
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For elderly in the community they can get them to travel to community vaccination hubs.

I’m not sure the specifics of how it works in care homes but in Ireland we’ve already vaccinated all our care home residents with Pfizer or Moderna.
 
Pogue Mahone said:
For elderly in the community they can get them to travel to community vaccination hubs.

I’m not sure the specifics of how it works in care homes but in Ireland we’ve already vaccinated all our care home residents with Pfizer or Moderna.
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Ah Moderna is easier logistically I believe not that we have any yet! On Pfizer the advice changed last minute because initially our rollout plan was care homes first but one week before Pfizer arrived it was stated you couldn’t move the vaccine after delivery. I think a few weeks later that changed back to say you could and they did a pilot in North Wales but we’d already started on staff and with Oxford about to arrive decided to leave that to GPs. Hopefully it works on the elderly...
 
It seems to have gone noticeably quiet on the questions surrounding the delay of the second dose of the Pfizer vaccine to 12 weeks and whether this has an effect on the efficacy after the second dose.
 
Mickeza said:
Ah Moderna is easier logistically I believe not that we have any yet! On Pfizer the advice changed last minute because initially our rollout plan was care homes first but one week before Pfizer arrived it was stated you couldn’t move the vaccine after delivery. I think a few weeks later that changed back to say you could and they did a pilot in North Wales but we’d already started on staff and with Oxford about to arrive decided to leave that to GPs. Hopefully it works on the elderly...
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That’s interesting. I’m almost certain that care home residents got Pfizer as well as Moderna. Probably made life easier that we started a bit later so the advice re moving after delivery was already clear by then.
 
P-Ro said:
It seems to have gone noticeably quiet on the questions surrounding the delay of the second dose of the Pfizer vaccine to 12 weeks and whether this has an effect on the efficacy after the second dose.
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Not sure what news you’re expecting considering the first person on the planet to be vaccinated got their initial jab less than 8 weeks ago!
 
P-Ro said:
It seems to have gone noticeably quiet on the questions surrounding the delay of the second dose of the Pfizer vaccine to 12 weeks and whether this has an effect on the efficacy after the second dose.
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What news were you expecting? It hasn't even been 12 weeks since the 1st person anywhere received their pfizer vaccine and the news has been filled since then with undignified spats between the EU and pharmaceutical companies, vaccine nationalism, new variants, Northern Ireland, the EMA and AZ, continuing horrible numbers and promising new vaccine candidates.

The arguments have kind of worn out for now and all people can do is wait for whatever data we end up collecting.
 
mitChley said:
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How does this make sense, if the initial results said the vaccine was only 62% effective after 2 jabs? Yet it's 76% effective after one jab?

Doesn't the second jab make the immune response weaker if given after 3 weeks?
 
Mickeza said:
Wonder what they are going to use to rollout to 80 plus, the shielding and care homes. Logistically Pfizer is a nightmare which is why we’ve let the GPs with Oxford handle them.
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Italy has already done most of the care home residents with Pfizer, so it is possible. My region is scheduled to finish first and second doses by 23 February.
 
mitChley said:
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I like this news. I believe most of the other vaccines do not reduce transmission?

Scott Beasley (@SkyScottBeasley) Tweeted: Crucially, Oxford says the vaccine DOES stop transmission:

Oxford: “Analyses of PCR positive swabs in UK population suggests vaccine may have substantial effect on transmission of the virus with 67% reduction in positive swabs among those vaccinated”
 
Fluctuation0161 said:
I like this news. I believe most of the other vaccines do not reduce transmission?

Scott Beasley (@SkyScottBeasley) Tweeted: Crucially, Oxford says the vaccine DOES stop transmission:

Oxford: “Analyses of PCR positive swabs in UK population suggests vaccine may have substantial effect on transmission of the virus with 67% reduction in positive swabs among those vaccinated”
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Most (all?) of the other studies didn’t check. They only did PCR tests when clinically indicated (i.e. when symptomatic)
 
A bit more data from Novavax in the form of a slide presentation they made to the NY Academy of Science today.



Very small numbers involved in some of the efficacy reports, in particular from the SA trial, where there's 15:29 cases vaccine: placebo across the whole trial or 11:27 if you only consider the HIV- cohort. As far as I can see that does mean that in HIV+ subjects the ratio was 4:2 - not enough cases in that group to be statistically significant in themselves, but enough to mean that the results will need separate analysis, and more study.

Despite the small numbers in some categories they're still worth reporting because all vaccine companies/health providers will need to look at the same thing.

They also note that they've already made a SA targeted version of the vaccine in the lab. That's where their research team are going next.
 
redshaw said:
Poland and Sweden also not using the vaccine for over 60 and 65s. Looks like Belgium will be next.
https://www.politico.eu/article/fra...trazeneca-vaccine-for-people-younger-than-65/

This is problem with not testing many elderly plus there's a lot coming down the pipe with better data and efficacy.
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As well as the other vaccines, the AZ one could still end up with decent evidence in the elderly. They’ve a phase 3 study which is recruiting elderly subjects that started after the studies used to get the license. If that generates some decent results then all those recommendations could change.
 
Pogue Mahone said:
As well as the other vaccines, the AZ one could still end up with decent evidence in the elderly. They’ve a phase 3 study which is recruiting elderly subjects that started after the studies used to get the license. If that generates some decent results then all those recommendations could change.
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The odds must be high that they will.
 
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