I don't think Giggs can manage two games in a week - nor should we expect him too (though if anyone can prove you wrong...), thus I think it'll be Fellaini/Jones in there, which would be fine I think. Fellaini was better than Cleverley last week (though that wasn't a difficult feat to achieve) so he probably deserves to start ahead of him.
The other one is Rio - no way should we be playing RIo for 3 games in one week, asking for trouble I'd say... but with everyone injured, what else is there? He's obviously not going to play Fabio, so maybe Valencia right back with Smalling/Evans? Doubt it.
Think we'll see a return of Danny Welbeck to the side - probably at Nani's expense.