Kraftwerker
Formerly RedAddict
Actually, now that I think about it. Scholes + Anderson in the middle might be the choice. With the Internationals we can expect the majority of our team to have played mid-week and travelled long distances. That said, it is the start of the season, no one's going to be that tired. Perhaps Nani will miss out on travelling with Portugal, Scholes obviously won't be playing for England and Anderson would be somewhat of an unlikely starter as well. This gives us almost complete freshness in midfield.. but I think we'll go for what most would regard as our strongest available team. There's little reason not to at the start of the season..
Scholes Anderson is one of those midfield combos we should never play. It doesn't work.