Expect to see:
de Gea
Rafael Vidic Evans Evra
Carrick Fellaini
Valencia Rooney Nani
Hernandez
--
Amos; Smalling, Jones; Cleverley, Kagawa; Welbeck, van Persie
I hope Young doesn't manage to find a place, and Giggs will be left out after playing the full game against Liverpool.
It might be Smalling who keeps his place over Evans, and he was probably our best defender against Liverpool. If it is, then it'll probably be Ferdinand and Evans against Shaktar. The other option is Smalling goes to Right Back in Shaktar and Ferdinand replaces Vidic (although he'll probably replace Evans). I think now is the time to be rotating our defence a fair bit as we should be winning our next five Premier League games and not losing to Shaktar away (and beating Sociedad at home).
Moyes might rather start RvP and replace him after an hour, but I think Hernandez deserves another start so I'd do it the other way around and play Robin in the Champions League.