Ryan Giggs and Darren Fletcher could run out against Wolverhampton Wanderers on Saturday, but Nani is facing a battle to be fit for the Manchester derby.
United's assistant manager Mike Phelan delivered the team news at the Reds' Carrington training base as Sir Alex Ferguson has been struck down with a virus, similar to the one that caused a number of players to miss the midweek trip to Turkey.
Darron Gibson appears hardest hit and definitely won't feature against Wolves, while Phelan said "one or two others" did not train on Friday and will be assessed on the morning of the match.
Veteran winger Giggs has been out of action since United drew 2-2 with West Bromwich Albion on 16 October after aggravating a hamstring strain but is now back in training.
"Ryan's started his preparation for the matches, but whether he'll be available on Saturday, we're not quite sure just yet," Phelan said. "We'll assess that in training."
Fletcher, who rolled his ankle during Tuesday's 3-0 win against Bursaspor, has shown "positive signs that he could recover". Phelan added: "We'll have another look at him this morning and hopefully he'll be available."
There was less positive news for Nani. The Portuguese winger suffered a groin strain and was forced off at the Ataturk Stadium in Bursa. He won't be fit to face Wolves, but could return for Wednesday's crucial clash with Manchester City.
"There's a possibility Nani will play against City," says Phelan. "He reported in yesterday and felt better than he expected. We'll progress him as quickly as we can with a view to having him play next week."