Yeah I wouldn't be keen on it. I guess Pfizer see it as a pretty big potential market though, especially with the current narrative that kids are the monsters of the pandemic.
The vaccines | vaxxed boosted unvaxxed? New poll
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In the latest episode of the United Hour Podcast, Nik (@Rood) is joined by CEO Duncan Drasdo and Financial Director Andy Green from the Manchester United Supporters Trust for a special episode on all things behind the scenes at Old Trafford including a brief history of MUST and their aims today, views on INEOS and Sir Jim Ratcliffe so far, and the Old Trafford regeneration.
I'd imagine that as the Moderna supplies start coming in they'll be used for the under 50s and the AZ vaccines will be used primarily for second doses for those already done.
Also talk of the Novavax vaccine being rolled out in May which will also be used for the under 50s
Assuming the Novavax gets regulatory approval - then it may start arriving in the UK supply in June.
They're being very cagey on dates at the moment - understandably so, but it looks like for the UK, production is underway now, sometime in April for approval, and first batches going through fill/finish in May. That would mean significant volume of usable (fully QC tested) batches sometime in June - if it all goes to plan. Probably getting up to their planned capacity in July or beyond. Realistically they won't be major contributors (anywhere in the world) until Q3/4.
Then again, they may be trying to do that, under-promise and over-deliver thing. Nobody wants to be another AstraZeneca.
J&J (who've so far only delivered around 5 million doses in the US - all imported as bulk product from their Netherlands plant) lost 15 million doses earlier this month in a mistake at their US manufacturing sub-contractor. The FDA have put shipments from the plant on hold pending investigation according to:
https://thehill.com/policy/healthcare/545856-shipments-of-johnson-johnson-vaccine-halted
https://thehill.com/policy/healthcare/545856-shipments-of-johnson-johnson-vaccine-halted
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Wouldn't want to be the guy who messed up
If you’v got the right QA procedures in place it shouldn’t be possible for human error to cause such a massive cock-up. FFS.
J&J need to sort their shit out here. The one dose approach and relatively high storage temperatures is an absolute lifesaver for third world countries.
I'd immunise my kids in a flash after such studies as it will contribute to efforts to get to the HIT.
The German doctor who first raised the clotting issue has said there is only a very small risk, that is a number of orders of magnitude less than getting covid, so we should continue vaccinating.
My only question would be "Are the risks associated with the Astrazeneca vaccine greater than the risks from contracting Covid?"
If the answer is a negative then carry on and get vaccinated.
Is there any correlation with those who have suffered the reaction being the same as those who are at most risk of contracting Covid i.e immuno suppressed, respiratory illnesses etc?
If the answer is a negative then carry on and get vaccinated.
Is there any correlation with those who have suffered the reaction being the same as those who are at most risk of contracting Covid i.e immuno suppressed, respiratory illnesses etc?
Good news about AZ/Oxford and the UK variant
https://www.news-medical.net/news/2...ffective-against-B117-SARS-CoV-2-variant.aspx
https://www.news-medical.net/news/2...ffective-against-B117-SARS-CoV-2-variant.aspx
On the kids issue, and the does vaccination reduce infection as well as disease question, a bit of (good) news from Israel.
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
On the kids issue, and the does vaccination reduce infection as well as disease question, a bit of (good) news from Israel.
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
Isn't that exactly what you might expect? The move to vaccinate kids will presumably only gain urgency if we can't get to HIT without vaccinating 12-18 year olds or even younger.
Not that they know about yet. The problems seem to be with young, healthy females.
The question for that group is whether the risk of the vaccine is higher than the risk of catching the virus, and then ending up in hospital with it, also considering there are now other vaccines available. Regulators are still trying to understand that.
The Oxford/AstraZeneca group have updated their UK trials data. They now have more cases (because the trial period was that much longer), and they've been able to split out data for those with the UK variant versus those with the original one.
The good news is that the efficacy looks good - probably benefiting from the longer time period from vaccination to infection. The quoted efficacy (all symptom severity) now looks like 70% against the UK variant, 81% against the original strain. Which is not a surprise since we're also seeing high levels of protection in the analysis coming from the UK rollout.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00628-0/fulltext
The good news is that the efficacy looks good - probably benefiting from the longer time period from vaccination to infection. The quoted efficacy (all symptom severity) now looks like 70% against the UK variant, 81% against the original strain. Which is not a surprise since we're also seeing high levels of protection in the analysis coming from the UK rollout.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00628-0/fulltext
Do we have a feel from previous vaccines, how long we might expect the Ox/AZ and J&J vaxs to take to reach maximum protection? I've seen a few people suggest that it builds up over a longer time (so, for example, the South African trial might not be as bad as it appeared) but don't really know how much to take from that.
So far I've only been a bit sore on my arm and jaded. Nothing I couldn't be anyway from my normal life.
Oh, and body akes like hell, but that's been around for years.
Oh, and body akes like hell, but that's been around for years.
I've been told 2 weeks until you are considered protected.
But that information might be outdated.
Seems to be a bit of radio silence on the clotting issue from U.K.
That’s the first time (I think?) we’ve seen any suggestion of reduced vaccine efficacy against UK variant. Although confidence intervals are wide and efficacy decent overall.
Not really. The MHRA initial review has identified 5 cases of CSVT that may be related (by timing) to the vaccine in men under the age of 60. Which doesn't seem to fit the pattern observed in Germany/Norway where the main clusters have been seen in women.
They're now asking all haematology units to review all CSVT and newly diagnosed thrombocytopenia cases in the period to make sure that vaccine status is checked and they get added to the database even if the doctors treating them identified (or thought they had identified) other causes.
Meanwhile the national guidance to hospital doctors has been updated to:
https://b-s-h.org.uk/about-us/news/covid-19-updates/
Which gives some methodology cautions (like how to do the PF4 test) as well as treatment advice. They're operating a daily specialist panel session to analyse any new data and to give advice to hospital doctors who have patients to diagnose or treat.
The raw advice to people receiving the vaccine now has sustained headache, blurred vision, multiple unexplained bruises/pinprick bruises as warnings to "seek medical advice".
Pfizer has announced it's vaccine remains 91% effective after 6 months. Excellent news for the concerns about protection dropping off after a few months.
Fantastic. Getting closer and closer to an annual booster being all that’s required.
Still be a huge job every year
Not all that much work in addition to what we already do with annual flu jab (1 million people got flu vaccine in Ireland last year)
Yeah but nearly 5m in a short space of time no?
My wife's arm is still dead 4 weeks after the AZ jab.
A hassle but doable. Combination of pharmacists and at your place of work. Obviously the hope would be efficacy lasting > 12 months.
Do we think an annual booster might be necessary for all adults, or just those identified as falling within the various higher risk categories (à la flu)?
What are doing in normal life that makes your arm sore. Oh wait a moment...
Not that the drop off is necessarily linear, but 94% to 91% in 6 months gives hope a booster might not be needed so frequently. Or at least it can be staggered.
Pfizer press release on efficacy (now coming in at around 91% using data from their clinical trial group) and with a first look at the SA strain where a small (800 person) trial has seen 100% efficacy. Don't get too carried away with that 100% just yet though - it actually relates to 0 cases in the vaccinated group versus 6 cases of the variant in the unvaccinated - good news though.
https://www.businesswire.com/news/home/20210401005365/en/
https://www.businesswire.com/news/home/20210401005365/en/
Sleeping on it.
BBC News - Covid: Europe's vaccine rollout 'unacceptably slow' - WHO
https://www.bbc.co.uk/news/world-europe-56600660
I really hope things can start picking up in Europe in coming months. With the positive news about the vaccines if we can get acceptable numbers of people protected we can start to slowly see some normality again.
https://www.bbc.co.uk/news/world-europe-56600660
I really hope things can start picking up in Europe in coming months. With the positive news about the vaccines if we can get acceptable numbers of people protected we can start to slowly see some normality again.
I don't think anybody listens much to the WHO anymore. They're quickly dismissed by pretty much everybody in Italy after their handling of the pandemic.
There are few surprises in Europe despite certain news stories. We were about 15% down on expected deliveries during Q1. During Q2 we are expecting 400m doses to arrive, a 4x increase and almost enough for everybody on the continent. It's then up to individual countries to get them into arms.
Ahh the old stranger.....
Here I was thinking the point of sleeping on it being that It didn't feel as usual.
In ireland we were meant to get 1m, it’s already down to just over 800k. This company is a disgrace