We do have a few weaknesses at the back.

Lucas and Gerrard's passing against Villa was woeful, thus couldn't pass our way out of trouble as we usually do. Hopefully, it was a blip. Agger is suspect and prone to a huge mistake every match. Wouldn't be surprised if you get at least one penalty because of him. How we've kept a clean sheet is more to do with our 'possession football' than reliance on him.
And I would play Valencia against Enrique. I think Antonio could be too wily for Jose, more so than the direct but predictable Zaha. The main question will be do you press us high away from home, or do you sit back and try to play on the counter? And will Rooney ever pass to Van Persie?