Moyes won't rest too many here, if anyone, it's going to be Ferdinand and he'll probably be the only one. There's a decent gap between this game and the City game. City also have to travel away while we're in Manchester for the next four games so next to no travelling to do at all. That should be the one big plus and allow us to get the likes of Hernandez, Kagawa, and Nani up to speed over the next set of games (except for Nani in this one, obviously).
Changes from Crystal Palace:
Rafael > Fabio (if he's fit)
Evans/Smalling > Ferdinand
Fellaini > Anderson
Giggs > Young
de Gea, Vidic, Evra, Valencia, Carrick, Rooney, van Persie to keep their places.
A lot of people are saying we'd be resting too many players for an important Champions League game where we really need to get off to a winning start. However, I think three of these four changes make the side stronger while freshening things up at the same time. So much so, that if Hernandez started over van Persie, I wouldn't be arsed at all. I still think Hernandez and Kagawa will make their appearances from the bench, regardless of how the game is going.
Edit: Scratch that on Kagawa, if he's been ill then he's probably going to have to try and make sub appearances against Liverpool and West Brom rather than here.